Background: Public health policies in the area of food and diets tend to separate recommendations on food safety and nutrition. However, food products can simultaneously have risks and benefits. Risk-benefit assessment (RBA) seeks to integrate the assessment of both risks and benefits to aid complex decision-making using a multidisciplinary approach. In this study, a systematic literature review of recent RBA studies was performed, focusing on food consumption and human health following earlier reviews by Boué, et al. (2015) and Thomsen, et al. (2021). Results: A total of 50 new RBA studies were reviewed since 20 May 2014. Our current literature review shows that the majority of RBA studies conducted in recent years remain focused on seafood, with studies on fish alone comprising 34% of all studies; the focus being on the benefits of fish consumption versus contaminant exposure. Most of the studies have been conducted in Europe (n = 31) and Asia (n = 11). Conclusion: RBA has the potential to be applied more widely to other food choices such as alternative proteins, yet application remains limited to specific applications and contaminant/nutrient case studies. In recent years, a few RBA studies have been reported on less mainstream food sources and one specifically on novel foods. Novel foods offer a unique application space for RBA as their development is focused heavily on the benefits to the consumer, society, and environment, yet there remains uncertainty as to their safety.
Boué G, Guillou S, Antignac JP, Le Bizec B, Membré JM. Public health risk-benefit assessment associated with food consumption–a review. European Journal of Nutrition & Food Safety. 2015:32-58.
Assunção R, Alvito P, Brazão R, Carmona P, Fernandes P, Jakobsen LS. Building capacity in risk-benefit assessment of foods: Lessons learned from the RB4EU project. Trends in Food Science and Technology. 2019;91(March):541-8. doi: 10.1016/j.tifs.2019.07.028.
Pires SM, Boué G, Boobis A, Eneroth H, Hoekstra J, Membré JM, Persson IM, Poulsen M, Ruzante J, van Klaveren J, Thomsen ST, Nauta MJ. Risk Benefit Assessment of foods: Key findings from an international workshop. Food Res Int. 2019 Feb;116:859-869. doi: 10.1016/j.foodres.2018.09.021. Epub 2018 Sep 10. PMID: 30717016.
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Hoekstra J, Hart A, Boobis A, Claupein E, Cockburn A, Hunt A, Knudsen I, Richardson D, Schilter B, Schütte K, Torgerson PR, Verhagen H, Watzl B, Chiodini A. BRAFO tiered approach for Benefit-Risk Assessment of Foods. Food Chem Toxicol. 2012 Nov;50 Suppl 4:S684-98. doi: 10.1016/j.fct.2010.05.049. Epub 2010 May 28. PMID: 20546818.
Hart A, Hoekstra J, Owen H, Kennedy M, Zeilmaker MJ, de Jong N, Gunnlaugsdottir H. Qalibra: a general model for food risk-benefit assessment that quantifies variability and uncertainty. Food Chem Toxicol. 2013 Apr;54:4-17. doi: 10.1016/j.fct.2012.11.056. Epub 2012 Dec 20. PMID: 23261673.
Leino O, Karjalainen AK, Tuomisto JT. Effects of docosahexaenoic acid and methylmercury on child's brain development due to consumption of fish by Finnish mother during pregnancy: a probabilistic modeling approach. Food Chem Toxicol. 2013 Apr;54:50-8. doi: 10.1016/j.fct.2011.06.052. Epub 2011 Jun 23. PMID: 21723361.
Verhagen H, Andersen R, Antoine JM, Finglas P, Hoekstra J, Kardinaal A, Nordmann H, Pekcan G, Pentieva K, Sanders TA, van den Berg H, van Kranen H, Chiodini A. Application of the BRAFO tiered approach for benefit-risk assessment to case studies on dietary interventions. Food Chem Toxicol. 2012 Nov;50 Suppl 4:S710-23. doi: 10.1016/j.fct.2011.06.068. Epub 2011 Jul 7. PMID: 21763387.
The EFSA's 6th Scientific Colloquium Report - Risk-benefit analysis of foods: methods and approaches. EFSA Supporting Publications 2006;4(3):116E.
Naska A, Ververis E, Niforou A, Pires SM, Poulsen M, Jakobsen LS. Novel foods as red meat replacers - an insight using Risk Benefit Assessment methods (the NovRBA project). EFSA Supporting Publications. 2022;19(5):7316E-E. doi: 10.2903/sp.efsa.2022.en-7316 CO - ESPFCQ.
Thomsen ST, Assunção R, Afonso C, Boué G, Cardoso C, Cubadda F, Garre A, Kruisselbrink JW, Mantovani A, Pitter JG, Poulsen M, Verhagen H, Ververis E, Voet HV, Watzl B, Pires SM. Human health risk-benefit assessment of fish and other seafood: a scoping review. Crit Rev Food Sci Nutr. 2022;62(27):7479-7502. doi: 10.1080/10408398.2021.1915240. Epub 2021 May 6. PMID: 33951954.
Moher D, Liberati A, Tetzlaff J, Altman DG; PRISMA Group. Reprint--preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Phys Ther. 2009 Sep;89(9):873-80. PMID: 19723669.
Ralston NVC, Kaneko JJ, Raymond LJ. Selenium health benefit values provide a reliable index of seafood benefits vs. risks. J Trace Elem Med Biol. 2019 Sep;55:50-57. doi: 10.1016/j.jtemb.2019.05.009. Epub 2019 May 31. PMID: 31345365.
Kosker AR. Metal and fatty acid levels of some commercially important marine species from the northeastern Mediterranean: benefits and health risk estimation. Environ Monit Assess. 2020 May 11;192(6):358. doi: 10.1007/s10661-020-08287-1. PMID: 32394291.
Sulimanec Grgec A, Jurasović J, Kljaković-Gašpić Z, Orct T, Rumora Samarin I, Janči T. Potential risks and health benefits of fish in the diet during the childbearing period: Focus on trace elements and n-3 fatty acid content in commonly consumed fish species from the Adriatic Sea. Environmental Advances. 2022;8:100226. doi: 10.1016/j.envadv.2022.100226.
Sulimanec Grgec A, Kljaković-Gašpić Z, Orct T, Tičina V, Sekovanić A, Jurasović J, Piasek M. Mercury and selenium in fish from the eastern part of the Adriatic Sea: A risk-benefit assessment in vulnerable population groups. Chemosphere. 2020 Dec;261:127742. doi: 10.1016/j.chemosphere.2020.127742. Epub 2020 Jul 23. PMID: 32745738.
Barchiesi F, Branciari R, Latini M, Roila R, Lediani G, Filippini G, Scortichini G, Piersanti A, Rocchegiani E, Ranucci D. Heavy Metals Contamination in Shellfish: Benefit-Risk Evaluation in Central Italy. Foods. 2020 Nov 23;9(11):1720. doi: 10.3390/foods9111720. PMID: 33238443; PMCID: PMC7700650.
Fang T, Liang Y, Yang K, Zhao X, Gao N, Li J. Benefit-risk assessment of consuming fish and shrimp from a large eutrophic freshwater lake, China. Journal of Food Composition and Analysis. 2022;114. doi: 10.1016/j.jfca.2022.104835.
Gladyshev MI, Sushchik NN, Anishchenko OV, Makhutova ON, Kalachova GS, Gribovskaya IV. Benefit-risk ratio of food fish intake as the source of essential fatty acids vs. heavy metals: A case study of Siberian grayling from the Yenisei River. Food Chemistry. 2009;115(2):545-50. doi: 10.1016/j.foodchem.2008.12.062.
Murray CJ. Quantifying the burden of disease: the technical basis for disability-adjusted life years. Bull World Health Organ. 1994;72(3):429-45. PMID: 8062401; PMCID: PMC2486718.
Salomon JA, Haagsma JA, Davis A, de Noordhout CM, Polinder S, Havelaar AH, Cassini A, Devleesschauwer B, Kretzschmar M, Speybroeck N, Murray CJ, Vos T. Disability weights for the Global Burden of Disease 2013 study. Lancet Glob Health. 2015 Nov;3(11):e712-23. doi: 10.1016/S2214-109X(15)00069-8. PMID: 26475018.
Devleesschauwer B, Havelaar AH, Maertens de Noordhout C, Haagsma JA, Praet N, Dorny P, Duchateau L, Torgerson PR, Van Oyen H, Speybroeck N. DALY calculation in practice: a stepwise approach. Int J Public Health. 2014 Jun;59(3):571-4. doi: 10.1007/s00038-014-0553-y. Epub 2014 Apr 21. PMID: 24748107.
Vellinga RE, Sam M, Verhagen H, Jakobsen LS, Ravn-Haren G, Sugimoto M, Torres D, Katagiri R, Thu BJ, Granby K, Hoekstra J, Temme EHM. Increasing Seaweed Consumption in the Netherlands and Portugal and the Consequences for the Intake of Iodine, Sodium, and Exposure to Chemical Contaminants: A Risk-Benefit Study. Front Nutr. 2022 Jan 6;8:792923. doi: 10.3389/fnut.2021.792923. PMID: 35071298; PMCID: PMC8770327.
He M, Lyu X. Application of BRAFO-tiered approach for health benefit-risk assessment of dark tea consumption in China. Food Chem Toxicol. 2021 Dec;158:112615. doi: 10.1016/j.fct.2021.112615. Epub 2021 Oct 15. PMID: 34656696.
Oloye DA*, Agbaje RB, Olatunji CA and Olawale-Olakunle OEOloye DA*,Agbaje RB,Olatunji CA,Olawale-Olakunle OE. Anti-nutrient and mineral properties of Complementry Food produced from Malted Red Sorgum and Defatted Soybean Flour Blend. . 2017 doi: 10.29328/journal.afns.1001006; 1: 033-038
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Christopher E Ekpenyong*Christopher E Ekpenyong*. Lemongrass tea consumption and changes in Acid-Base Balance and Electrolyte homeostasis. . 2018 doi: 10.29328/journal.afns.1001016; 2: 041-051
Jamal Safi* and Asad AshourJamal Safi*,Asad Ashour. Environmental Risk factors associated with Breast Cancer in Gaza Strip. . 2019 doi: 10.29328/journal.afns.1001017; 3: 001-009
Mohammad Raies Ul Haq*, Asima H and Aarif BMohammad Raies Ul Haq*,Asima H,Aarif B. Possible links between consumption of A1 “like” milk And Type 1 Diabetes (T1D) . . 2019 doi: 10.29328/journal.afns.1001018; 3: 010-016
Oscar Almazán del Olmo* and Indira PérezOscar Almazán del Olmo*,Indira Pérez. The sugarcane byproducts to a food security in an ecofriendly way: A review. . 2022 doi: 10.29328/journal.afns.1001031; 6: 001-005
Aline Mayrink de Miranda*Aline Mayrink de Miranda*. Agaricus brasiliensis (Sun mushroom) and its therapeutic potential: A review. . 2022 doi: 10.29328/journal.afns.1001032; 6: 006-015
Asit Kumar Chakraborty*Asit Kumar Chakraborty*. Coronaviruses have reached at Pre-elimination Stage with Nine Amino Acid Spike Deletions and Forty-nine Nucleotide 3’-UTR Deletions. Int J Clin Virol. 2024: doi: 10.29328/journal.ijcv.1001060; 8: 031-044
Julian A Purrinos* and Ramzi YounisJulian A Purrinos*, Ramzi Younis. Sinonasal Myxoma Extending into the Orbit in a 4-Year Old: A Case Presentation. Arch Case Rep. 2024: doi: 10.29328/journal.acr.1001099; 8: 075-077
Alexandra Maloof*, David Torres Barba, Santiago Ramirez Nuño, Nainjot K Bains, Ignacio A Zepeda, Armando Gallegos, Hyeri You, Wesley Thompson, Jia Shen, Robert El-Kareh and Luis R CastellanosAlexandra Maloof*, David Torres Barba, Santiago Ramirez Nuño, Nainjot K Bains, Ignacio A Zepeda, Armando Gallegos, Hyeri You, Wesley Thompson, Jia Shen, Robert El-Kareh, Luis R Castellanos. Improving Cardiac Rehabilitation Referral Rates in Patients with Coronary Heart Disease from Diverse Communities Using an Electronic Order System. J Cardiol Cardiovasc Med. 2024: doi: 10.29328/journal.jccm.1001187; 9: 102-109
H Pérez-Aguilar*, M Lacruz-Asaro and F Arán-AisH Pérez-Aguilar*, M Lacruz-Asaro, F Arán-Ais. Evaluation of Biostimulants Based on Recovered Protein Hydrolysates from Animal By-products as Plant Growth Enhancers. J Plant Sci Phytopathol. 2023 doi: 10.29328/journal.jpsp.1001104; 7: 042-047
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Palestine College of Nursing, Khan Younis, Gaza Strip, Palestine
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Department of Agricultural Economics, Agribusiness and Extension, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana
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